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Clinical Application of Serum Amyloid a (SAA)

Infectious diseases are a common type of clinical disease. Infectious diseases have a wide variety of pathogens, various infection routes, and individual differences in symptoms and signs. If the diagnosis and effective treatment are not timely and effective, serious consequences may occur.


Therefore, how to make early diagnosis and/or differential diagnosis of infectious diseases is a practical problem to be solved urgently in clinical practice.


Serum amyloid A diagnostic reagent (Serum Amyloid A, SAA) is a non-specific acute phase reactive protein, and its clinical value as an inflammatory marker has received extensive attention in recent years.


The change of SAA level has important clinical value for the early diagnosis, risk assessment, curative effect observation and prognosis evaluation of infectious diseases.


In addition to being elevated in bacterial infections, SAA is also significantly elevated in viral infections. According to its degree of elevation or in combination with other indicators, it can indicate bacterial or viral infections, thus making up for the fact that currently commonly used inflammatory markers cannot indicate viruses. Insufficient infection.


Ⅰ. Clinical significance of SAA diagnostic reagents


1. Rapid diagnosis of bacterial and viral infections.


2. In the early stage of infection and weak inflammatory stimuli, SAA is more sensitive than CRP and can provide better identification.


3. It has a sensitive response and can be used as a sensitive indicator to reflect the control of infection and inflammation.


4. SAA diagnostic reagents are widely used in auxiliary diagnosis of infectious diseases, risk prediction of coronary heart disease, dynamic monitoring of curative effect and prognosis of tumor patients, monitoring of transplant rejection, and monitoring of rheumatoid arthritis disease improvement.


5. The combined detection of SAA, CRP, and PCT can better reflect the complementary advantages, and has an additional basis for the diagnosis and differential diagnosis of bacterial and viral infections, and can better reflect the clinical significance that cannot be reflected by a single index.


6. The combination of SAA and CRP can provide powerful data for the differential diagnosis of early bacterial and viral infections, and guide the use of antibiotics, especially in the early diagnosis of pediatric infectious diseases, neonatal sepsis, and early bacterial infections in infants and young children. The identification of virus infection has greater significance than a single item.


7. The increase of SAA and hs-CRP concentrations may have a positive correlation with predicting the risk of cardiovascular events in healthy people in the future, and the increase of both indicators is more meaningful for predicting the risk of cardiovascular events.


8. SAA infection diagnostic test is widely used in auxiliary diagnosis of infectious diseases, risk prediction of coronary heart disease, dynamic observation of curative effect and prognosis of tumor patients, observation of transplant rejection, and observation of improvement of rheumatoid arthritis. 10mg/L is normal, which is consistent with the CRP reference range.


Ⅱ. SAA diagnostic reagents in the early diagnosis of virus infection


SAA increases rapidly in both bacterial and viral infections, and CRP only increases in bacterial infection. Based on this feature, the combined detection of SAA and CRP is more unique than CRP alone.


Ⅲ. SAA diagnostic reagents in the early diagnosis of bacterial infection


SAA index was more sensitive than CRP in early infection, increased earlier, and decreased faster and larger in recovery. SAA is more sensitive than CRP to weak inflammatory stimuli in the early stages of infection and may provide better differentiation.


Ⅳ. Differential diagnosis of SAA diagnostic reagents in bacterial infection and viral infection


The simultaneous detection of both provides powerful data for the differential diagnosis of early bacterial and viral infections. Especially in the early diagnosis of pediatric infectious diseases and neonatal sepsis.


The SAA infection diagnostic test has greater significance than a single test in the early identification of bacterial and viral infections in infants and young children.


The three combined detections of SAA, CRP and PCT can effectively identify bacterial infection and viral infection, predict the risk of cardiovascular events, and evaluate the prognosis of tumor diseases.

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