Troponin is a protein on myocyte myofibrillin that regulates the calcium-mediated interaction between actin and myosin. It is present in myocardium and skeletal muscle and consists of troponin T, troponin I and troponin C subunits. Troponin is a tropomyosin binding subunit that interacts with actin and tropomyosin. Troponin I is an inhibitory subunit that inhibits actomyosin ATPase activity; Troponin C is the only subunit that binds calcium and causes contraction of skeletal or myocardial muscle. There are two types of cardiac troponins, namely cardiac troponin T and cardiac troponin I. Cardiac troponin T can be detected in serum 2 hours after acute myocardial infarction, with a long existence time and high concentration. The value of cardiac troponin I in the early diagnosis of acute myocardial infarction is the same as that of cardiac troponin T.
Myocardial troponin I generally refers to troponin I, cardiovascular test results in reduced under the condition of no clinical significance commonly, but if the rise, and eliminate excessive after muscle injury caused by the situation, often prompted the myocardial injury, also may be caused by other reasons, need to see a doctor in a timely manner, thus clear diagnosis.
1. Myocardial injury: elevated troponin I in cardiovascular tests can indicate myocardial injury, usually caused by acute myocardial infarction, severe cardiac insufficiency, etc. Acute myocardial infarction is commonly due to myocardial ischemia, caused by a lack of heart blood can cause myocardial cell injury, and serious cardiac insufficiency may bow | shock, lead to multiple organ damage, can also lead to myocardial damage. In addition to increased troponin, most of the above patients will have pain in the precardiac area and other symptoms, and electrocardiogram may also appear abnormal performance. In addition, severe pneumonia, severe pancreatitis and other related diseases can also cause respiratory failure, myocardial injury, shock, renal insufficiency and other manifestations due to the progression of inflammation. Therefore, timely detection of troponin I is necessary. If there is an increase in troponin I, it may indicate uncontrolled inflammation.
2. Other reasons: if the body troponin excretion from the kidney is reduced, there will also be a rise in troponin, usually indicating kidney problems, such as renal insufficiency. In conclusion, elevated troponin in cardiovascular tests may occur in a variety of conditions, and the causes should be further identified and targeted management based on the clinical characteristics of patients.