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Details on the Application of CRP, PCT and NT-proBNP in Emergency Clinic

Ⅰ. Clinical application of crp rapid test kit

C-reaction protein (CRP) was discovered in 1930 by Tillet and Francis. Initially, they observed that the serum of some acute patients could react with the capsular C-polysaccharide of Streptococcus pneumoniae, and subsequently confirmed that the substance that could react with the C-polysaccharide was a protein.

Therefore, this protein is named C-reaction protein (CRP). CRP is an acute-phase protein synthesized by hepatocytes when the body is subjected to inflammatory stimuli such as microbial invasion or tissue damage. CRP is the "gold indicator" of acute-phase response.

1. The concentrations of crp rapid test kit are significantly increased in inflammation, tissue damage and after surgery.

2. The level of CRP in the blood begins to rise 4-6 hours after the disease, and is detected 6-12 hours later, and is peaked 24-48 hours later. It is 100-1000 times higher than the normal value, and the increase is positively correlated with the degree of infection, and the duration is similar to the course of disease.

3. When the lesion is improved, its content will decrease rapidly and return to normal in 1 week (T1/2 about 19h).

4. The changes are not affected by individual differences of patients, body states and therapeutic drugs.

Ⅱ. Clinical application of PCT diagnosis reagents

PCT is a protein that is elevated in plasma during severe bacterial, fungal and parasitic infections as well as sepsis and multiple organ failure. PCT is not elevated in autoimmune, allergic and viral infections.

Localized limited bacterial infection, mild infection, and chronic inflammation do not cause it to rise. Bacterial endotoxin plays an important role in induction. PCT diagnosis reagents reflect the active degree of systemic inflammatory response.

Factors that influence PCT levels include the size and type of infected organs, the type of bacteria, the level of inflammation, and the status of the immune response. In addition, PCT can only be measured 1 to 4 days after major surgery in a small number of patients.

1. Differential diagnosis

Early diagnosis of severe infection. Differential diagnosis of bacterial and viral infections with PCT diagnosis reagents.

2. Use medication as directed

Accurately guide the time of using antibiotics. Accurately guide the dosage of antibiotics. effectively avoid the abuse of antibiotics.

3. Response prognosis

Response to sepsis, MODS prognosis. Observe antibiotic efficacy.

4. Dynamic Monitoring

Monitoring of infection severity in critically ill patients. Monitoring postoperative infection with PCT diagnosis reagents.

Ⅲ. Clinical application of NT-proBNP diagnosis reagent

NT-proBNP is a peptide substance of natriuretic, diuretic and vasodilator, which can promote vasodilation, reduce blood pressure and regulate water and electrolyte balance. It may also inhibit renin-angiotensin-aldosterone system, as well as anti-myocardial fibrosis.

The diagnostic value and accuracy of NT-proBNP diagnosis reagent in the diagnosis of cardiovascular diseases in patients with suspected heart failure and different severity of heart failure have been fully recognized. Many current consensus statements and guidelines have recommended it as a major component of diagnostic tests for HF.

1. NT-proBNP detection improves the diagnosis of heart failure (HF).

2. Combined application of PCT has the highest diagnostic accuracy compared with CRP diagnosis reagent alone.

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