Recently, Hipro Biotechnology was issued by Hebei Provincial Drug Administration with the registration certificate of homocysteine detection kit (fluorescence method). How terrible is high homocysteine? Hypertension, stroke, neural tube malformation, congenital malformation, preeclampsia, Parkinson's disease, slow fetal growth, chronic renal failure... It's all about it! Today, let's have a good talk about homocysteine.
In March 2016, 'the Expert Consensus on Diagnosis and Treatment of H-type Hypertension' was published in 'Chinese Journal of Hypertension. The purpose of formulating this consensus is to develop a medical evidence-based hypertension treatment plan that is consistent with the characteristics of the Chinese hypertension population, respond to the current situation of the high incidence of stroke in China, and provide the possibility for accurate treatment of hypertension patients. Epidemiological data show that the incidence of stroke in China is the highest in the world. The number of current cases, the mortality rate, and the annual cost of hospitalization place a huge burden on the Nation, society, and the family.
Among all kinds of risk factors, hypertension is undoubtedly the first risk factor for cardiovascular and cerebrovascular diseases, and people with hypertension accompanied by increased HCY are more at high risk for cardiovascular and cerebrovascular diseases. Compared with the European and American populations, the Chinese population with the same degree of elevated blood pressure is more likely to have a stroke; In previous clinical trials, the incidence of stroke was also higher in the Chinese population than the incidence of coronary heart disease. In this Consensus, it is clearly recommended that patients with hypertension should be routinely tested for HCY!
Homocysteine (HCY), a metabolite of methionine in the body, is a kind of vascular damage amino acid. HCY can cause a large amount of oxidative free radicals to cause damage to endothelial cells and increase lipid peroxidation and oxidized low density, thus causing damage and destruction to blood vessels. Under the action of HCY, damaged blood vessel walls form plaques, promoting atherosclerosis. Therefore, under the synergistic effect of hypertension and high HCY, cardiac and cerebrovascular events such as myocardial infarction and cerebral infarction are easily induced.
1. Prevention and treatment of cardiovascular diseases
(1) The relationship between elevated HCY and atherosclerosis (AS)
Elevated HCY in the blood can promote the occurrence of systemic atherosclerosis and thrombosis, and induce cerebral infarction and myocardial infarction.
(2) HCY level and risk of cardiovascular disease
As plaques were observed by intracerebral ultrasound, it was observed that when the plasma HCY concentration was less than 8umol/L, the plaques were smaller (0.17-0.76mm), and when > was 8umol/L, the plaques were significantly larger (0.27-1.04, P <0.001), indicating a positive correlation with the degree of coronary artery lesions. Mild and moderate HCY levels increased the risk of death from cardiovascular disease by 4-6 times. Each 5 μmol/L increase in plasma total HCY levels increased the risk of CHD by 60% in men and 80% in women.
2. HCY and neurological diseases
Cerebrovascular disease is a major disease that seriously endangers human health at present. In recent years, with the in-depth development of molecular biology, the role of HCY in stroke has been increasingly paid attention to. It is generally believed that plasma HCY >15umol/L is hyperHCY blood anemia, and the increase of plasma HEY level in the general population is less than 5%, while in stroke patients it can be up to 30-40%
Elevated HCY is an important risk factor associated with stroke. The latest data from the United States shows that stroke rates in men in late middle age, men in the 55-64 age group are three times more likely to have a stroke than men in the 45-54 age group.
High HCY is an important factor in Alzheimer's disease and Parkinson's disease.
3. Prevention and treatment of diabetes and its complications
HCY level can be used as an independent risk factor for macrovascular disease in patients with type 2 diabetes, and increased HCY level is more serious in patients with diabetes associated with renal, retinal, and vascular complications.
4. Prevention and treatment of complications of chronic renal failure
Chronic renal failure (CRF) patients generally have hyperHCY, the incidence of which is 33 times that of normal people.
5. Prevention and treatment of pulmonary thromboembolism
Studies have shown that the risk of deep vein thrombosis is significantly increased by hyperHCY (>20μmol/L), and the incidence of deep vein thrombosis is increased by 4 times by hyperHCY.
High HCY is an independent risk factor for the incidence of pulmonary thromboembolism (PTE) in the Han Chinese population, and reducing HCY can reduce the risk of venous thromboembolism (VTE) in the Chinese population.
6. Dynamic monitoring of HCY level and scientific guidance of folic acid supplement for pregnant and puerpera
The increase of HCY will lead to the decrease of neonatal weight and the increase of neonatal defects (neurovascular defects, cleft lip, and palate, etc.). Preeclampsia and gestational diabetes are at increased risk; Lead to placental vascular diseases, and then affect the placental blood flow, and then affect the fetus; And the increase of HCY is also easy to cause recurrent early abortion.
l People with CHD, cerebrovascular disease or peripheral AS disease;
l Have high blood pressure, diabetes, obesity, smokers;
l Early onset or early death of patients with CHD or AS, especially in their immediate family;
l There are yellow tumors or yellow warts;
l Familial hyperlipidemia;
l Male over 40 years old, pregnant group, pregnant women.
Reference range of HCY
The normal value of HCY: 5-15μmol/L
Ideal value: <10μmol/L
More than 15μmol/L: hyperHcy
Mild: 15-30 mu mol/L
Moderate: 31-100 mu mol/L
Severe: > 100 mu mol/L
Detection Method: The fluorescence method
Specimen type/size: serum /15ul
Detection time: 420S
Linear range: 2.5~60umol/L